Research · Media · Conversation

Tracking the science and conversation around suPAR.

A source-first index of peer-reviewed research, professional analysis, and expert talks—organized for discovery and review.

16 curated entries16 original source links

How the index works

Explore topics

16 entries

Curated source index

Research, analysis, and expert media

Original sources · Editorial context · Direct links

Jeffrey Bland presenting in the source video.

VideoThumbnail based on supplied source frame

Personalized Lifestyle Medicine InstituteNovember 3, 2025

Presented by Jeffrey Bland

Intro to the Clinical Applications of Epigenetics and Artificial Intelligence to Immuno-Metabolism

Jeffrey Bland presents a public talk from the Personalized Lifestyle Medicine Institute on epigenetics, artificial intelligence, and immunometabolism.

Third-party expert presentation

Editorial contextThe presentation reflects the speaker's perspective and should be reviewed in its full source context.

Expert PerspectivesWatch source

Report

Official report source · Guggenheim Securities

Guggenheim SecuritiesDecember 10, 2024

The Century Project (v.76): suPAR, a New Biomarker of Aging and Inflammation

A Guggenheim Securities report examining suPAR in the context of chronic inflammation, aging, and healthspan research.

Industry research report

Editorial contextThis is a market and industry perspective rather than a peer-reviewed scientific publication.

AgingView original

UK Biobank · JAHA 2026July 7, 2026

33,963

participants

Median follow-up · approximately 14 years

Research

Journal of the American Heart AssociationJuly 7, 2026

Proteomics-Based Soluble Urokinase Plasminogen Activator Receptor Levels Are Associated With Adverse Cardiovascular Outcomes in the General Population: Insights From the UK Biobank

In 33,963 UK Biobank participants followed for a median of roughly 14 years, a proteomics-based suPAR measure was associated with adverse cardiovascular outcomes.

Peer-reviewed longitudinal cohort · New research

Editorial contextThis study evaluated a proteomics-based measure in an observational cohort rather than an interchangeable clinical suPAR concentration.

CardiovascularView original

TOPCAT ancillary study2025

406

participants

Heart failure with preserved ejection fraction

Research

ESC Heart Failure2025

Soluble urokinase plasminogen activator receptor and outcomes in HFpEF: A TOPCAT ancillary study

In a 406-participant TOPCAT ancillary cohort, higher baseline suPAR was associated with cardiovascular death, cardiac arrest, or heart-failure hospitalization after adjustment for other factors.

Peer-reviewed ancillary cohort study

Editorial contextA relatively small observational ancillary cohort cannot establish causality or support a standalone prognostic decision rule.

CardiovascularView original

Illustrated overview of organs and conditions reported in association with elevated suPAR.

ResearchFigure 4 · Rasmussen et al., Frontiers in Immunology (CC BY 4.0)

Frontiers in ImmunologyDecember 2, 2021

suPAR and systemic chronic inflammation: a scientific review

This review synthesizes research on how suPAR is produced, factors associated with circulating levels, and findings reported across chronic diseases.

Peer-reviewed narrative review

Editorial contextA narrative review, not clinical validation; an author reports suPAR-related patents and company interests.

FoundationsView original

Four study charts compare aging measures across suPAR quintiles.

ResearchFigure 1 · Rasmussen et al., Journals of Gerontology

The Journals of Gerontology: Series AJanuary 18, 2021

Elevated suPAR and markers of accelerated aging

In the longitudinal Dunedin Study, elevated suPAR at midlife was associated with a faster measured pace of biological aging and differences in physical and cognitive function.

Peer-reviewed longitudinal cohort

Editorial contextOne midlife New Zealand cohort; the findings do not define a clinical cutoff or prove that suPAR drives aging.

AgingView original

Prospective observational study2021

participants

One-year biomarker follow-up after bariatric surgery

Research

Endocrine2021

suPAR and high-sensitivity C-reactive protein after bariatric surgery

In 48 adults undergoing bariatric surgery, hsCRP declined consistently while suPAR increased transiently before moving toward baseline over 12 months.

Peer-reviewed prospective observational study

Editorial contextThe small study demonstrates context-dependent biomarker behavior but does not establish clinical outcomes or intervention efficacy.

FoundationsView original

Acute medical cohort2020

25,497

patients

Incident chronic and acute kidney-disease outcomes

Research

Frontiers in Cell and Developmental Biology2020

Elevated suPAR as a risk marker for incident kidney disease in acute medical patients

Among 25,497 acutely hospitalized medical patients, higher suPAR at emergency-department admission was associated with greater subsequent risk of chronic and acute kidney disease.

Peer-reviewed longitudinal clinical cohort

Editorial contextFindings from an acutely ill hospital population are observational and do not establish causality or a general clinical threshold.

Kidney DiseaseView original

Inter99 population cohort2019

3,225

participants

Lifestyle patterns, longitudinal suPAR, and mortality

Research

Immunity & Ageing2019

Healthy lifestyles reduce suPAR and mortality in a Danish general population study

In 3,225 Inter99 participants, healthier lifestyle patterns were associated with lower longitudinal suPAR levels, while higher suPAR was associated with greater all-cause mortality during follow-up.

Peer-reviewed longitudinal population cohort

Editorial contextObservational associations do not establish that changing suPAR levels changes mortality or other health outcomes.

AgingView original

Danish population cohort2019

5,347

participants

Dietary quality, circulating suPAR, and mortality

Research

British Journal of Nutrition2019

suPAR, dietary quality, and mortality in a Danish population cohort

In 5,347 Danish participants, lower dietary-quality scores were associated with higher suPAR, and higher suPAR was associated with greater all-cause mortality.

Peer-reviewed population cohort

Editorial contextThe observational design remains subject to residual confounding and does not establish causal relationships among diet, suPAR, and mortality.

Population HealthView original

Type 1 diabetes cohort2019

667

participants

Cardiovascular events, kidney function, and mortality

Research

Diabetes Care2019

suPAR and cardiovascular, kidney, and mortality outcomes in type 1 diabetes

In a cohort of 667 people with type 1 diabetes, higher suPAR was associated with cardiovascular events, kidney-function decline, and all-cause mortality.

Peer-reviewed observational cohort

Editorial contextThis disease-specific cohort does not establish causality or validate suPAR as a standalone clinical decision tool.

CardiovascularView original

Healthy-adult study2019

155

participants

Analytical and biological determinants of circulating suPAR

Research

Clinical Biochemistry2019

Analytical, biochemical, and clearance considerations for suPAR in healthy individuals

A study of 155 healthy adults examined analytical and biological factors that may influence circulating suPAR, including renal clearance, receptor biology, tissue expression, and physiological variability.

Peer-reviewed analytical and biological determinants study

Editorial contextThe small healthy-adult cohort does not define clinical reference ranges or establish interpretation across patient populations.

FoundationsView original

Malmö Diet and Cancer StudyMarch 2017

5,381

baseline participants

Population replication · Kidney International Reports

Research

Kidney International ReportsMarch 2017

suPAR and kidney function in the Malmö population study

This population-based study examined suPAR in relation to impaired kidney function and subsequent decline, providing replication outside the original referred cohorts.

Peer-reviewed population cohort

Editorial contextObservational European cohort data; assay methods, baseline kidney function, and other risk factors can influence the relationship.

Kidney DiseaseView original

Projected decline in kidney filtration over ten years across four baseline suPAR quartiles.

ResearchFigure 1 · Hayek et al., NEJM

The New England Journal of MedicineNovember 12, 2015

suPAR and future chronic kidney disease risk

This longitudinal study reported that higher suPAR levels were associated with declining kidney function and incident chronic kidney disease.

Peer-reviewed prospective cohort

Editorial contextThe human evidence is observational and comes from referred cardiovascular cohorts; kidney function and residual confounding affect interpretation.

Kidney DiseaseView original

Inter99 general population2014

5,538

participants

Smoking, age, obesity, activity, and circulating suPAR

Research

Biomarker Insights2014

Risk factors associated with circulating suPAR in a general population

In 5,538 Danish participants, smoking, age, and obesity were independently associated with higher suPAR, while the association with physical activity weakened after multivariable adjustment.

Peer-reviewed population-based observational study

Editorial contextAssociations between participant characteristics and suPAR do not establish directionality, causality, or clinical reference thresholds.

Population HealthView original

Copenhagen population cohortSeptember 2010

2,602

participants

Approximately 13 years of follow-up

Research

Journal of Internal MedicineSeptember 2010

suPAR and long-term health outcomes in a Danish population cohort

In 2,602 Copenhagen adults followed for approximately 13 years, higher baseline suPAR was associated with cancer, cardiovascular disease, type 2 diabetes, and mortality.

Peer-reviewed prospective cohort

Editorial contextObservational findings from a predominantly White Danish cohort do not establish causation or a screening threshold.

Population HealthView original

About this archive

A useful place to begin, not the last word.

suPAR Index gathers publicly available research, talks, reports, and professional analysis in one searchable place. Every entry links directly to its source.

Evidence types are labeled, editorial context is shown on each card, and source-specific disclaimers appear where applicable.